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	Provedor de dados BJMBR (2) Autor Cavalcante,L.A. (2) Garcia-Abreu,J. (2) Mendes,F.A. (2) Moura Neto,V. (2) Silva,L.C.F. (2) Carvalho,S.L. (1) Onofre,G. (1) Onofre,G.R. (1) Weissmüller,G. (1) Werneck,C.C. (1) Mais... Palavra-chave Astrocytes (2) Midbrain (2) Axonal growth (1) Chondroitin sulfate (1) Glycosaminoglycans (1) Heparan sulfate (1) Midline (1) Neuron-glia interactions (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2003 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Astroglial cells derived from lateral and medial midbrain sectors differ in their synthesis and secretion of sulfated glycosaminoglycans BJMBR Onofre,G.R.; Werneck,C.C.; Mendes,F.A.; Garcia-Abreu,J.; Moura Neto,V.; Cavalcante,L.A.; Silva,L.C.F.. Astroglial cells derived from lateral and medial midbrain sectors differ in their abilities to support neuritic growth of midbrain neurons in cocultures. These different properties of the two types of cells may be related to the composition of their extracellular matrix. We have studied the synthesis and secretion of sulfated glycosaminoglycans (GAGs) by the two cell types under control conditions and ß-D-xyloside-stimulated conditions, that stimulate the ability to synthesize and release GAGs. We have confirmed that both cell types synthesize and secrete heparan sulfate and chondroitin sulfate. Only slight differences were observed between the proportions of the two GAGs produced by the two types of cells after a 24-h labeling period. However, a marked... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycosaminoglycans; Astrocytes; Neuron-glia interactions; Midbrain. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200014 Sulfated proteoglycans as modulators of neuronal migration and axonal decussation in the developing midbrain BJMBR Cavalcante,L.A.; Garcia-Abreu,J.; Mendes,F.A.; Moura Neto,V.; Silva,L.C.F.; Onofre,G.; Weissmüller,G.; Carvalho,S.L.. Proteoglycans are abundant in the developing brain and there is much circumstantial evidence for their roles in directional neuronal movements such as cell body migration and axonal growth. We have developed an in vitro model of astrocyte cultures of the lateral and medial sectors of the embryonic mouse midbrain, that differ in their ability to support neuritic growth of young midbrain neurons, and we have searched for the role of interactive proteins and proteoglycans in this model. Neurite production in co-cultures reveals that, irrespective of the previous location of neurons in the midbrain, medial astrocytes exert an inhibitory or nonpermissive effect on neuritic growth that is correlated to a higher content of both heparan and chondroitin sulfates... Tipo: Info:eu-repo/semantics/article Palavras-chave: Astrocytes; Axonal growth; Chondroitin sulfate; Heparan sulfate; Midline; Midbrain. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800005 Registros recuperados: 2 Primeira ... 1 ... Última

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